Association between covid-19 vaccination and postmenopausal bleeding

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The vaccination against Covid-19 was the crucial point for controlling the pandemic caused by SARS-CoV-2. However, several symptoms and complaints have been attributed to vaccination against Covid-19even knowing that the benefits outweigh the risks, it is important to carry out studies to clarify possible effects of the vaccine, so that the population is informed and feels safe about vaccination.


One of the symptoms reported by women is the occurrence of post-menopausal bleeding. In July 2022, an article was published in American Journal of Obstetrics and Gynecology with the aim of evaluating whether vaccination against covid-19 is really associated with an increase in the diagnosis of postmenopausal bleeding, across a large and diverse cohort of women.

The authors selected female patients aged over 55 years at the time of vaccination against covid-19, between December 1, 2020 and May 31, 2021, excluding patients with a history of hysterectomy. Among the 485,644 women who met the inclusion criteria, 47% were non-white with a median age of 67 years (range 55-105), with 95.4% receiving one dose of the mRNA vaccine: 52.4% received BNT162B2 (Pfizer-Biontech) and 43% received mRNA-1273 (Moderna). During the pre-vaccination interval (40 days before), the incidence of postmenopausal bleeding was 0.39% (95% CI, 0.38%-0.41%), increasing slightly after vaccination to 0.47 % during the first interval (95% CI, 0.45%-0.49%) and then decreasing to 0.43% (95% CI, 0.41%-0.45%) during the second observation interval of the patients (bilateral Cochran-Armitage test for linear trend in proportions P value=0.004). The proportion of women whose diagnosis of postmenopausal bleeding was delayed more than two months from the date of onset of bleeding was similar at the three consecutive time intervals (23.6%, 22.8%, and 20.4%, respectively). , P=0.39).

Read too: Association of vaccination against covid-19 during pregnancy with incidence of SARS-CoV-2 infection in infants


The authors concluded that vaccination against covid-19 was associated with a slight increase in the rate of postmenopausal bleeding. However, in absolute numbers, the event represents less than one in 1000 additional women diagnosed with bleeding after vaccination compared to before vaccination. Among premenopausal women, vaccination against covid-19 was associated with an increase of less than one day in the menstrual cycle, but no change in the duration of menstruation. Evidence provides reassurance that vaccination against covid-19 is not associated with a significant increase in the incidence of postmenopausal bleeding, and vaccination is safe for patients after menopause.


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